1-[2-(2-Hydroxy ethoxy)-ethyl]-piperazine

Name	1-Hydroxyethoxyethylpiperazine
Synonyms	HEP HEEP 1-piperazidine Hydroxyzine Impurity 1 Quetiapine HEEP IMpurity 1-Hydroxyethoxyethylpiperazine 1-hydroxyethylethoxypiperazine N-hydroxyethoxyethyl piperazine Hydroxyethylethoxypiperazine, 1- 2-[2-(1-piperazine)ethoxy]ethanol 2-[2-(1-piperazinyl)ethoxy]ethanol 2-[2-(1-piperazinyl)ethoxy)ethanol 2-(2-hydroxyethoxy)ethyl)piperazine 2-(2-piperazin-1-YL-ethoxy)-ethanol N-(2-hydroxyethoxy)ethyl)piperazine 2-[2-(1-piperazidine)ethoxy]ethanol) Ethanol, 2-[2-(1-piperazinyl)ethoxy]- 1-[2-(2-hydroxyethoxy)ethyl]piperazine 1-[2-(2-hydroxyethoxy)ethyl] piperazine 1-[2-(2-hydroxyethoxy) ethyl] piperazine 1-[2-(2-Hydroxy ethoxy)-ethyl]-piperazine 1-[2-(2-hydroxyethoxyl)-ethyl] piperazine 1-[2-(2-hydroxyethoxy)ethyl]piperazinediium N-(2-(2-hydroxyethoxy)ethyl)piperazine dihydrochloride Quetiapine IMpurity (1-[2-(2-Hydroxyethoxy)ethyl]piperazine) N-(2-Hydroxyethylethoxy) piperazine 2-[2-(1-Piperazinyl)ethoxy]ethanol 1-(2-(2-Hydroxyethoxy)ethyl) piperazine
CAS	13349-82-1
EINECS	1533716-785-6
InChI	InChI=1/C8H18N2O2/c11-6-8-12-7-5-10-3-1-9-2-4-10/h9,11H,1-8H2/p+2
InChIKey	FLNQAPQQAZVRDA-UHFFFAOYSA-N

Molecular Formula	C8H18N2O2
Molar Mass	174.24
Density	1.061g/mLat 25°C(lit.)
Boling Point	112-114°C0.25mm Hg(lit.)
Flash Point	>230°F
Solubility	Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly)
Vapor Presure	7.57E-05mmHg at 25°C
Appearance	Liquid
Specific Gravity	1.061
Color	Clear colorless to yellow-brownish
pKa	14.41±0.10(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Room temperature
Refractive Index	n20/D 1.497(lit.)
Physical and Chemical Properties	Boiling point 112-114 ℃(33Pa), relative density of 1.061.
Use	Used as a pharmaceutical Intermediate

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection
WGK Germany	3
HS Code	29335990
Hazard Class	IRRITANT

NIST chemical information	information provided by: webbook.nist.gov (external link)
Use	an intermediate of hydroxyzine, a weak neuroleptic. used as pharmaceutical intermediates organic synthesis, pharmaceutical synthesis intermediates, can be used for the synthesis of hydroxyzine hydrochloride raw material (2192-20-3).
production method	is obtained from the condensation of piperazine with chloroethoxyethanol. Piperazine hexahydrate and piperazine dihydrochloride were added to the reaction pot, heated to 140 °c with stirring, and distilled to obtain piperazine hydrochloride. It was cooled to 120 °c and chloroethoxyethanol was added dropwise. After completion of the addition, the temperature was raised to 150-155 ° C., the reaction was carried out for 4H, and the mixture was put into cold ethanol while hot, and cooled to 0-5 ° C. Filtering, filtrate plus sodium hydroxide solution neutralization, filtering sodium chloride, distilled ethanol, to obtain the finished product. The yield was 60%.

Last Update：2024-04-09 20:49:11

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1-[2-(2-Hydroxy ethoxy)-ethyl]-piperazine

1-[2-(2-Hydroxy ethoxy)-ethyl]-piperazine Request for Quotation